The San Francisco Giants wrap up a Wednesday afternoon at Oracle Park when they host the Minnesota Twins on September 23, 2026, with first pitch scheduled for 3:45 PM ET. Cesar Perdomo gets the ball for San Francisco against Minnesota left-hander Connor Prielipp in what shapes up as a matchup of two young arms working through their development at the big-league level. With the regular season winding toward its final days, every game carries real weight — and this one is no exception for a Giants club looking to close out September on a strong note at home.

Giants vs. Twins Pitching Matchup: Perdomo vs. Prielipp

Both starters here are names you'll want to know rather than names you already do. Cesar Perdomo draws the start for the Giants, a young arm the organization has been developing, and Wednesday gives him a chance to make a statement in front of the home crowd at Oracle Park. Connor Prielipp gets the nod for Minnesota, another prospect-track pitcher who will be tested by a Giants lineup that has enough bats to make any young starter uncomfortable.

Without ERA or win-loss figures available entering Wednesday, the honest read is this: both pitchers are relative unknowns at this level, and that creates genuine unpredictability. The bullpens on both sides figure to play a significant role regardless of how long the starters last.

San Francisco Giants Lineup

• 1. Jonah Cox, 2B
• 2. Turner Hill, CF
• 3. Victor Bericoto, LF
• 4. Bo Davidson, RF
• 5. Andrew Knizner, C
• 6. Brett Harris, 1B
• 7. Marcelo Mayer, DH
• 8. Shay Whitcomb, 3B
• 9. Christian Koss, SS

Minnesota Twins Lineup

• 1. Luke Keaschall, RF
• 2. Austin Martin, LF
• 3. Josh Bell, DH
• 4. Ryan Jeffers, C
• 5. Brooks Lee, 3B
• 6. Royce Lewis, 2B
• 7. Emmanuel Rodriguez, CF
• 8. Aaron Sabato, 1B
• 9. Ben Ross, SS

Keys to Watch at Oracle Park

• Mayer in the middle of the order: Marcelo Mayer batting seventh as the DH is a name worth circling. The former top prospect gets a chance to contribute in a lineup that needs its middle bats to produce.
• Royce Lewis for Minnesota: Lewis sliding into the six-hole at second base is interesting lineup construction from the Twins. He has the ability to change a game in a hurry, and the Giants' pitching staff will need to stay sharp when he steps in.
• Josh Bell as the Twins' anchor: Batting third and playing DH, Bell is Minnesota's most experienced middle-of-the-order presence. How Perdomo handles Bell early will set the tone for his outing.
• Oracle Park conditions: Late September at Oracle Park can mean cooling afternoon air and marine layer — conditions that historically suppress offense and favor the pitching staff. Worth keeping in mind as the lineups settle in.

Prediction

This one has the feel of a low-scoring, competitive game decided by a handful of plays. With two young starters who are difficult to project with confidence, the team that gets the better bullpen performance and capitalizes on its best scoring chances will likely come away with the win. The Giants get the home-field edge and the comfort of a familiar Oracle Park environment in the final weeks of the regular season. Edge: Giants, 3-2.